Ju Kim Hyoun, Moghaddar Nasir, Clark Sam, van der Werf Julius H J, de Las Heras-Saldana Sara
School of Environmental and Rural Science, University of New England, Armidale, New South Wales, Australia.
AGBU, a Joint Venture of NSW Department of Primary Industries and Regional Development and University of New England, Armidale, New South Wales, Australia.
PLoS One. 2025 May 27;20(5):e0324034. doi: 10.1371/journal.pone.0324034. eCollection 2025.
This study used whole-genome sequence data on 406 beef cattle (203 Hanwoo and 203 Angus) to detect signatures of selection using four different methods; integrated haplotype score (iHS), Rsb, XP-EHH, and runs of homozygosity (ROH). Based on Rsb and XP-EHH analysis, 36 and 21 genomic regions differed significantly between Angus and Hanwoo breeds. Within breeds, we identified 108 regions (76 in Hanwoo and 32 in Angus) with the ROH analysis and 331 regions with the iHS method (298 in Hanwoo and 33 in Angus). The candidate genes related to meat quality, such as HSPA9 and LPL, were found within Hanwoo, while genes associated with growth and meat quantity traits, including ACTC1 and TMEM68, were identified within Angus. This study can assist in understanding the selection history of these breeds and identifying the genomic regions associated with the traits selected for in the breeding programs for these cattle breeds.
本研究使用了406头肉牛（203头韩牛和203头安格斯牛）的全基因组序列数据，通过四种不同方法检测选择信号；综合单倍型评分（iHS）、Rsb、XP-EHH和纯合子连续片段（ROH）。基于Rsb和XP-EHH分析，安格斯牛和韩牛品种之间有36个和21个基因组区域存在显著差异。在品种内部，我们通过ROH分析确定了108个区域（韩牛76个，安格斯牛32个），通过iHS方法确定了331个区域（韩牛298个，安格斯牛33个）。在韩牛中发现了与肉质相关的候选基因，如HSPA9和LPL，而在安格斯牛中鉴定出了与生长和肉量性状相关的基因，包括ACTC1和TMEM68。本研究有助于了解这些品种的选择历史，并确定与这些肉牛品种育种计划中所选性状相关的基因组区域。
