Borsetto Daniele, Cheng Jordan, Payne Karl, Nankivell Paul, Batis Nikolas, Rao Kanishka, Bhide Shreerang, Li Feng, Kim Yong, Mehanna Hisham, Wong David
School of Cancer Sciences, Institute of Head and Neck Studies and Education, University of Birmingham, Birmingham, United Kingdom.
School of Dentistry, University of California Los Angeles, Los Angeles, California, United States of America.
Crit Rev Oncog. 2018;23(3-4):235-245. doi: 10.1615/CritRevOncog.2018027689.
Head and neck squamous cell carcinoma (HNSCC) manifests in the mucosal epithelial lining of the oral cavity, oropharynx, hypopharynx, nasopharynx or larynx and has a tremendous disease burden worldwide. Smoking and alcohol consumption were once major risk factors, but HPV-associated infection has emerged as the major contributor to HNSCC occurrence in developed countries. Circulating biomarker evaluations in biofluids, also known as liquid biopsy, are an attractive alternative for cancer screening as they are minimally invasive, potentially low cost, and easily repeatable on a serial basis. This review summarizes the current knowledge and potential of assessing circulating blood and salivary HPV DNA and HPV antibodies for the surveillance of HPV-positive HNSCC. Additionally, the biological underpinnings of the presence and relevance of circulating HPV DNA is discussed.
头颈部鳞状细胞癌（HNSCC）表现于口腔、口咽、下咽、鼻咽或喉部的黏膜上皮，在全球范围内疾病负担巨大。吸烟和饮酒曾是主要风险因素，但在发达国家，人乳头瘤病毒（HPV）相关感染已成为HNSCC发病的主要促成因素。生物流体中的循环生物标志物评估，也称为液体活检，是癌症筛查的一种有吸引力的替代方法，因为它们微创、潜在成本低且易于连续重复进行。本综述总结了评估循环血液和唾液中HPV DNA及HPV抗体用于监测HPV阳性HNSCC的现有知识和潜力。此外，还讨论了循环HPV DNA存在及相关性的生物学基础。
