The First Affiliated Hospital/Clinical Medical School, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Genecology Research Centre, University of the Sunshine Coast, Maroochydore DC, QLD, Australia.
PLoS One. 2019 Sep 23;14(9):e0221045. doi: 10.1371/journal.pone.0221045. eCollection 2019.
Human papillomavirus (HPV) related tumours account for a significant proportion of head and neck squamous cell carcinomas (HNSCCs) in developed countries. They respond better to chemo- and radio-therapy, and have a better stage specific prognosis. To establish their prevalence in China, we assessed a series of histology confirmed HNSCCs collected in Zhejiang and Guangdong provinces by PCR for HPV DNA and by immunohistochemistry for p16 protein status. Among 303 HNSCCs, HPV DNA was detected in 26.4%, with HPV16 DNA in 71% of these. Of HNSCC located in the oropharynx, 38.55% (32/83) were HPV+ve. In this series, p16 status was a relatively poor predictor of HPV status as detected by PCR. The stage specific survival time of HPV+ HNSCCs was significantly longer than for HPV- HNSCC. HPV status should be assessed for oropharyngeal cancers in China to assist with appropriate management, and prophylaxis against HPV infection should be considered to reduce the incidence of this disease.
人乳头瘤病毒（HPV）相关肿瘤占发达国家头颈部鳞状细胞癌（HNSCC）的很大一部分。它们对化疗和放疗的反应更好，并且具有更好的特定分期预后。为了确定它们在中国的流行程度，我们通过聚合酶链反应（PCR）检测 HPV DNA，通过免疫组织化学检测 p16 蛋白状态，对在浙江和广东省收集的一系列经组织学证实的 HNSCC 进行了评估。在 303 例 HNSCC 中，检测到 HPV DNA 的占 26.4%，其中 HPV16 DNA 占 71%。在口咽癌中，38.55%（32/83）为 HPV 阳性。在本系列中，p16 状态作为 PCR 检测 HPV 状态的相对较差的预测因子。HPV 阳性 HNSCC 的特定分期生存时间明显长于 HPV 阴性 HNSCC。在中国，应该对头颈部癌症的 HPV 状态进行评估，以辅助进行适当的治疗，并且应该考虑预防 HPV 感染以降低这种疾病的发病率。
