刺激内侧前脑束后下丘脑肾上腺素的合成
Hypothalamic adrenaline synthesis after stimulation of the medial forebrain bundle.
作者信息
Torda C
出版信息
Br J Pharmacol. 1977 Sep;61(1):5-8. doi: 10.1111/j.1476-5381.1977.tb09733.x.
Abstract
1 The problem of whether locally released noradrenaline can be methylated to adrenaline in the hypothalamus has been investigated. 2 During stimulation of the medial forebrain bundle (MFB) the hypothalamic adrenaline content increased somewhat, but the increase was not statistically significant (13%, mean of 10 experiments). 3 After inhibition of the activity of monoamine oxidase and catechol-O-methyltransferase this increase was much larger (80%, mean of 9 experiments). 4 Adrenalectomy did not prevent the rise in hypothalamic adrenaline after stimulation of the MFB. These results suggest that noradrenaline released during activity of noradrenergic hypothalamic structures may be methylated to adrenaline in the hypothalamus.
摘要
- 研究了下丘脑局部释放的去甲肾上腺素是否能甲基化为肾上腺素的问题。2. 在刺激内侧前脑束（MFB）期间，下丘脑肾上腺素含量略有增加，但这种增加在统计学上不显著（10次实验的平均值为13%）。3. 在抑制单胺氧化酶和儿茶酚-O-甲基转移酶的活性后，这种增加要大得多（9次实验的平均值为80%）。4. 肾上腺切除术并不能阻止刺激MFB后下丘脑肾上腺素的升高。这些结果表明，去甲肾上腺素能下丘脑结构活动期间释放的去甲肾上腺素可能在下丘脑中甲基化为肾上腺素。
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