Stiglick A, White N
Brain Res. 1977 Sep 9;133(1):45-63. doi: 10.1016/0006-8993(77)90048-8.
Unilateral lesions of various medial forebrain bundle components were assessed for their effects on lateral hypothalamic self-stimulation. Damage of areas containig nigrostriatal dopaminergic or ascending noradrenergic neurons had negligible effects on bar pressing, tail moving and alley running for hypothalamic stimulation. Lesions which appeared to destroy most or all of the catecholaminergic fibers in the posterior medial forebrain bundle virtually eliminated reinforced bar pressing and tail moving, but only partially suppressed alley running. The results suggest that brain stimulation reinforcement of the bar press and tail movement tasks depends upon the integrity of neural tissue in the area of the catecholaminergic pathways of the medial forebrain bundle, but not upon specific dopaminergic or noradrenergic systems. The data further suggest that the reinforcement of alley running is at least partially mediated by different neural tissue (possibly non-catecholaminergic) at the level of the posterior medial forebrain bundle lesions.
对内侧前脑束不同成分的单侧损伤进行了评估，以观察其对下丘脑外侧自我刺激的影响。包含黑质纹状体多巴胺能或上行去甲肾上腺素能神经元的区域受损，对下丘脑刺激时的压杆、摆尾和在直道上奔跑影响极小。那些似乎破坏了内侧前脑束后部大部分或全部儿茶酚胺能纤维的损伤，几乎消除了强化压杆和摆尾行为，但只是部分抑制了在直道上奔跑。结果表明，压杆和摆尾任务的脑刺激强化取决于内侧前脑束儿茶酚胺能通路区域神经组织的完整性，而不是特定的多巴胺能或去甲肾上腺素能系统。数据进一步表明，在直道上奔跑的强化至少部分是由内侧前脑束后部损伤水平的不同神经组织（可能是非儿茶酚胺能的）介导的。
