Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States; Department of Neurology, Mayo Clinic, Rochester, MN, United States; Women's Health Research Center, Mayo Clinic, Rochester, MN, United States.
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States.
Maturitas. 2018 Nov;117:64-77. doi: 10.1016/j.maturitas.2018.09.002. Epub 2018 Sep 14.
We investigated the association of personal, reproductive, and familial characteristics with bilateral oophorectomy performed for nonmalignant indications in a US population.
In an established cohort study, we used the records-linkage system of the Rochester Epidemiology Project (REP http://www.rochesterproject.org) to identify 1653 premenopausal women who underwent bilateral oophorectomy in Olmsted County, Minnesota between 1988 and 2007 for a nonmalignant indication. Each woman was matched by age (±1 year) to a population-based referent woman who had not undergone bilateral oophorectomy as of the index date. We used case-control analyses to investigate several characteristics associated with bilateral oophorectomy. Odds ratios and their 95% confidence intervals were adjusted for race, education, and income.
In the overall analyses, infertility was more common in women who underwent bilateral oophorectomy than in the controls, whereas use of oral contraceptives, a history of breast feeding, and fibrocystic breast disease were less common. The women who underwent bilateral oophorectomy weighed more than controls, had a higher body mass index and were younger at menarche. The associations were more pronounced for women who underwent the bilateral oophorectomy before age 46 years, and some associations were different for women with or without a benign ovarian indication. Reported family histories of uterine and other cancers were more common in women without a benign ovarian indication.
We identified a number of personal, reproductive, and familial characteristics that were associated with bilateral oophorectomy over a 20-year period. Our historical findings may help inform decision-making about oophorectomy in the future.
我们研究了个人、生殖和家族特征与美国人群中因非恶性指征行双侧卵巢切除术的关系。
在一项既定的队列研究中，我们使用罗切斯特流行病学项目（REP http://www.rochesterproject.org）的记录链接系统，确定了 1988 年至 2007 年间在明尼苏达州罗切斯特市因非恶性指征接受双侧卵巢切除术的 1653 名绝经前妇女。每位妇女都按年龄（±1 岁）与截至索引日期尚未接受双侧卵巢切除术的基于人群的对照妇女相匹配。我们使用病例对照分析来研究与双侧卵巢切除术相关的几个特征。比值比及其 95%置信区间根据种族、教育和收入进行了调整。
在总体分析中，与对照组相比，行双侧卵巢切除术的妇女不孕更为常见，而使用口服避孕药、母乳喂养史和纤维囊性乳腺病则较少见。行双侧卵巢切除术的妇女比对照组体重更重，体重指数更高，初潮年龄更小。对于 46 岁前接受双侧卵巢切除术的妇女，这些关联更为明显，对于有或没有良性卵巢指征的妇女，一些关联也不同。报告的家族史中有子宫和其他癌症的妇女在没有良性卵巢指征的妇女中更为常见。
我们确定了一些个人、生殖和家族特征，这些特征与 20 年来的双侧卵巢切除术有关。我们的历史发现可能有助于为未来的卵巢切除术决策提供信息。
