The Department of Cardiology, Royal Melbourne Hospital and the Department of Medicine, University of Melbourne, Melbourne, 3050, Australia.
Centre for Heart Rhythm Disorders (CHRD), South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.
Curr Cardiol Rep. 2018 Oct 12;20(12):137. doi: 10.1007/s11886-018-1082-8.
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans, affecting more than 33 million people globally. Its association with complex, resource intensive medical conditions such as stroke, heart failure and dementia have had profound impacts across existing health care structures. The global prevalence of AF has enjoyed significant growth despite significant improvement in our armamentarium for arrhythmia treatment.
Efforts aimed at curtailing the incidence, prevalence, or progression of AF have prompted re-evaluation of traditional frameworks for understanding and managing this debilitating disease. It is in this context that focus has shifted toward lifestyle-associated factors such as obesity, hypertension, sleep apnoea, exercise, alcohol and diet, as mechanistic drivers and putative targets for therapy. Compelling evidence exists for weight loss and management of associated risk factors to improve outcomes of AF treatment. This review will address the epidemiologic and mechanistic evidence that link lifestyle-associated factors with AF and in light of this analysis evaluate the clinical impacts of their upstream management. Traditional paradigms of AF are shifting in light of emerging evidence, such that risk factor modification has become positioned as the fourth pillar of AF management.
心房颤动(房颤)是人类最常见的持续性心律失常,影响全球超过 3300 万人。它与中风、心力衰竭和痴呆等复杂、资源密集型的医疗状况有关,对现有医疗结构产生了深远影响。尽管心律失常治疗手段有了显著改善,但全球房颤的患病率仍显著增加。
为了降低房颤的发病率、患病率或进展,人们重新评估了理解和管理这种使人衰弱的疾病的传统框架。正是在这种背景下,人们的注意力转向了与肥胖、高血压、睡眠呼吸暂停、运动、酒精和饮食等生活方式相关的因素,这些因素是发病机制的驱动因素和潜在的治疗靶点。有令人信服的证据表明,减轻体重和管理相关风险因素可以改善房颤治疗的结果。本综述将探讨与房颤相关的生活方式因素的流行病学和发病机制证据,并根据这一分析评估其上游管理的临床影响。鉴于新出现的证据,房颤的传统模式正在发生转变,因此,危险因素的改变已成为房颤管理的第四大支柱。