沉淀作为强化生物制药生产的一项使能技术。
Precipitation as an Enabling Technology for the Intensification of Biopharmaceutical Manufacture.
机构信息
Department of Biochemical Engineering, University College London, London WC1E 6BT, UK.
UCB Pharma, Slough, Berkshire, SL1 4BG, UK.
出版信息
Trends Biotechnol. 2019 Mar;37(3):237-241. doi: 10.1016/j.tibtech.2018.09.001. Epub 2018 Oct 10.
Abstract
Advances in precipitation have demonstrated the capability of purifying therapeutic proteins such as antibodies from biological sources in a scalable and cost-effective manner. We discuss the latest developments in the unit operation for downstream processing applications and provide a perspective on exploring precipitation for bioprocess intensification.
摘要
沉淀技术的进步已经证明，它能够以规模化和具有成本效益的方式，从生物来源中纯化治疗性蛋白质（如抗体）。我们讨论了下游加工应用中单元操作的最新进展，并就沉淀技术在生物工艺强化方面的应用提供了一些看法。
Zotero 插件