Wüstenberg P W, Schill H, Schröder J, Schumann L, Terpe H
Z Urol Nephrol. 1986 Nov;79(11):655-70.
In the renal compensatory adaptation after the definition and the description of the fundamental phenomena of the functional compensation as well as of the structural adaptation is reported on mediator concepts and on modulations of the renal adaptation processes. Issuing from the central position of the sodium balance a mediator concept on natriuretic hormones (Auriculin and Endoxin) is developed which is supplemented by the renotropin mediator concept. The authors deal with the modulation of the renal compensatory adaptation (e.g. influences of age diet and so on). The pharmacotherapeutic modulation of the renal compensatory adaptation is discussed with regard to the stimulation of the tubulosecretory transport of foreign substances with para-amino hippuric acid as principal substance (including own investigations with cyclopenthiazide [Benesal].
在对功能代偿以及结构适应的基本现象进行定义和描述之后，报告了肾脏代偿性适应中关于介质概念以及肾脏适应过程的调节。从钠平衡的核心地位出发，提出了一种关于利钠激素（耳尿钠肽和内毒素）的介质概念，并辅以促肾素介质概念。作者探讨了肾脏代偿性适应的调节（如年龄、饮食等的影响）。关于以对氨基马尿酸为主要物质刺激外来物质的肾小管分泌转运（包括用环戊噻嗪[贝内萨尔]进行的自身研究），讨论了肾脏代偿性适应的药物治疗调节。
