肾脏生长的体液调节。支持和反对存在循环促肾生长因子的证据。

Humoral regulation of renal growth. Evidence for and against the presence of a circulating renotropic factor.

作者信息

Austin H, Goldin H, Preuss H G

出版信息

Nephron. 1981;27(4-5):163-70. doi: 10.1159/000182049.

DOI:10.1159/000182049

Abstract

The stimuli for compensatory renal growth following a decrease in functioning renal mass have interested a number of investigators. The existence of a humoral incitor and/or regulator of renal growth, renotropin, has been postulated; and three types of experiments have been performed to determine its existence. These include parabiotic, in vivo, and in vitro assays. In general, the three different methodologies support the existence of a renotropic factor (or factors) but further investigations are needed to clarify its precise roles in compensatory renal growth.

摘要

功能性肾单位数量减少后引起代偿性肾生长的刺激因素已引起了许多研究者的兴趣。有人推测存在一种体液性肾生长刺激物和/或调节剂——促肾生长素；并且已经进行了三种类型的实验来确定其存在。这些实验包括联体生活、体内和体外试验。一般来说，这三种不同的方法都支持促肾生长因子的存在，但还需要进一步研究以阐明其在代偿性肾生长中的精确作用。