Shafiekhani Mojtaba, Mirjalili Mahtabalsadat, Vazin Afsaneh
Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran,
Ther Clin Risk Manag. 2018 Sep 28;14:1799-1812. doi: 10.2147/TCRM.S176079. eCollection 2018.
Managing psychological problems in patients admitted to intensive care unit (ICU) is a big challenge, requiring pharmacological interventions. On the other hand, these patients are more prone to side effects and drug interactions associated with psychotropic drugs use. Benzodiazepines (BZDs), antidepressants, and antipsychotics are commonly used in critically ill patients. Therefore, their therapeutic effects and adverse events are discussed in this study. Different studies have shown that non-BZD drugs are preferred to BZDs for agitation and pain management, but antipsychotic agents are not recommended. Also, it is better not to start antidepressants until the patient has fully recovered. However, further investigations are required for the use of psychotropic drugs in ICUs.
管理重症监护病房（ICU）患者的心理问题是一项巨大挑战，需要药物干预。另一方面，这些患者更容易出现与使用精神药物相关的副作用和药物相互作用。苯二氮䓬类药物（BZDs）、抗抑郁药和抗精神病药常用于危重症患者。因此，本研究讨论了它们的治疗效果和不良事件。不同研究表明，在躁动和疼痛管理方面，非BZD药物比BZDs更受青睐，但不推荐使用抗精神病药物。此外，在患者完全康复之前最好不要开始使用抗抑郁药。然而，在ICU中使用精神药物还需要进一步研究。
