Chen Shuaishuai, Ying Haijian, Du Juping, Zhu Xiaoli, Shi Jianfeng, Zhang Ying, Chen Shiyong, Shen Bo, Li Jun
Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province, Taizhou Enze Medical Center (Group), Linhai, China.
Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, China.
J Clin Lab Anal. 2019 Mar;33(3):e22695. doi: 10.1002/jcla.22695. Epub 2018 Oct 15.
Recently, clinical studies have described an association between albumin and the derived neutrophil to lymphocyte ratio (dNLR) with several diseases. This study was aimed to investigate the albumin-dNLR (ALB-dNLR) score in rheumatoid arthritis (RA) patients and assess its relationship with clinical and laboratory parameters of RA.
We retrospectively enrolled 127 RA patients, 155 osteoarthritis (OA) patients, and 155 healthy controls. The ALB-dNLR score was based on serum albumin level, neutrophil count, and white cell count. The Spearman's rank test was used to measure the correlations between ALB-dNLR score and disease activity as well as laboratory indexes.
The ALB-dNLR score was significantly higher in RA patients than in OA patients (P < 0.001) and in healthy controls (P < 0.001). The proportion of higher ALB-dNLR score has been raised along with increased disease activity (P < 0.001). The Spearman's rank test showed that ALB-dNLR score was positively associated with DAS28 score, CRP, ESR, IgA, and platelet count. Moreover, the receiver operating characteristic (ROC) curve showed that the area under the curve (AUC) of ALB-dNLR was 0.693 (95% CI: 0.631-0.755), which was higher than that of albumin (AUC: 0.625, 95% CI: 0.559-0.692) and dNLR (AUC: 0.680, 95% CI: 0.617-0.743) alone.
The results demonstrate that the ALB-dNLR score increased in RA patients. The ALB-dNLR score may be a useful marker to estimate the disease activity of RA patients.
最近，临床研究描述了白蛋白与衍生的中性粒细胞与淋巴细胞比率（dNLR）与多种疾病之间的关联。本研究旨在调查类风湿关节炎（RA）患者的白蛋白 - dNLR（ALB - dNLR）评分，并评估其与RA临床和实验室参数的关系。
我们回顾性纳入了127例RA患者、155例骨关节炎（OA）患者和155例健康对照。ALB - dNLR评分基于血清白蛋白水平、中性粒细胞计数和白细胞计数。采用Spearman秩检验来衡量ALB - dNLR评分与疾病活动度以及实验室指标之间的相关性。
RA患者的ALB - dNLR评分显著高于OA患者（P < 0.001）和健康对照（P < 0.001）。随着疾病活动度增加，ALB - dNLR评分较高的比例升高（P < 0.001）。Spearman秩检验显示，ALB - dNLR评分与DAS28评分、CRP、ESR、IgA和血小板计数呈正相关。此外，受试者工作特征（ROC）曲线显示，ALB - dNLR的曲线下面积（AUC）为0.693（95%CI：0.631 - 0.755），高于单独的白蛋白（AUC：0.625，95%CI：0.559 - 0.692）和dNLR（AUC：0.680，95%CI：0.617 - 0.743）。
结果表明RA患者的ALB - dNLR评分升高。ALB - dNLR评分可能是评估RA患者疾病活动度的有用标志物。
