Jiangxi Province Key Laboratory of Laboratory Medicine, Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi, China.
Future Oncol. 2018 Feb;14(3):229-239. doi: 10.2217/fon-2017-0339. Epub 2018 Jan 17.
To investigate diagnostic value of preoperative inflammatory biomarkers in pancreatic cancer (PCC).
MATERIALS & METHODS: Preoperative circulating Alb/Fib ratio, neutrophil/lymphocyte ratio (NLR), derived NLR (dNLR), platelet/lymphocyte ratio and lymphocyte/monocyte ratio were detected and calculated in 226 PCC individuals, 232 healthy controls and 142 additional cancer controls. Receiver-operating characteristic curve and area under the curve (AUC) were used to evaluate the diagnostic efficacy of PCC.
Combined circulating dNLR and Alb could effectively improve the diagnosis of PCC (AUC = 0.931), single dNLR could distinguish early-stage PCC and the disease from healthy controls (AUC = 0.895) and additional cancer controls (AUC = 0.794).
Circulating dNLR was an effective biomarker for diagnosis and identification of early-stage PCC. Combined dNLR and Alb could improve the diagnostic efficacy of the disease.
研究术前炎症生物标志物对胰腺癌（PCC）的诊断价值。
检测并计算了 226 名 PCC 患者、232 名健康对照者和 142 名其他癌症对照者的术前循环 Alb/Fib 比值、中性粒细胞/淋巴细胞比值（NLR）、衍生 NLR（dNLR）、血小板/淋巴细胞比值和淋巴细胞/单核细胞比值。采用受试者工作特征曲线和曲线下面积（AUC）评估 PCC 的诊断效能。
联合循环 dNLR 和 Alb 可有效提高 PCC 的诊断效能（AUC=0.931），单一 dNLR 可区分早期 PCC 与健康对照者（AUC=0.895）和其他癌症对照者（AUC=0.794）。
循环 dNLR 是诊断和识别早期 PCC 的有效生物标志物。联合 dNLR 和 Alb 可提高疾病的诊断效能。
