Department of Microbiology and Immunology, University of Iowa and.
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
J Clin Invest. 2018 Nov 1;128(11):4767-4769. doi: 10.1172/JCI124582. Epub 2018 Oct 15.
Enteroviruses, including subtype EV-A71, infect the brain, liver, heart, and other organs, causing a myriad of human diseases. This spectrum of disease is thought to be due, in part, to differential binding to host cells, and additional knowledge of enterovirus cell entry is essential for therapeutic development. In this issue of the JCI, Yeung et al. provide evidence of a novel EV-A71 entry factor, a host-produced tryptophan tRNA synthetase (hWARS), that facilitates entry of multiple subtypes of enteroviruses. hWARS is a cytoplasmic enzyme that is essential for translation but also upregulated and secreted during inflammatory processes. The results of this study support the notion of secreted hWARS as an unconventional virus entry factor that raises interesting questions about mechanisms by which inflammation and a tRNA synthetase facilitate viral pathogenesis.
肠道病毒，包括肠道病毒 A71 亚型，会感染大脑、肝脏、心脏和其他器官，引起多种人类疾病。据认为，这种疾病谱部分归因于与宿主细胞的不同结合，因此进一步了解肠道病毒的细胞进入对于治疗开发至关重要。在本期《临床研究杂志》中，Yeung 等人提供了证据表明，一种宿主产生的色氨酸 tRNA 合成酶（hWARS）是肠道病毒 A71 的新型进入因子，它促进了多种肠道病毒亚型的进入。hWARS 是一种细胞质酶，对翻译至关重要，但在炎症过程中也会被上调和分泌。该研究的结果支持了分泌型 hWARS 作为一种非传统的病毒进入因子的观点，这引发了关于炎症和 tRNA 合成酶如何促进病毒发病机制的有趣问题。
