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[左心室肥厚:如何确定病因?]

[Left ventricular hypertrophy : how to identity the cause ?].

作者信息

Bondue A

机构信息

Département de Cardiologie, Hôpital Erasme, ULB.

出版信息

Rev Med Brux. 2018;39(4):227-236.

Abstract

Left ventricular hypertrophy (LVH) is defined by an increase in left ventricular mass. LVH can be adaptive and related to an increase in left ventricular pressure or volume load, or can be related to a primary myocardial disease including sarcomeric, inflammatory or infiltrative disorders. The prevalence of left ventricular hypertrophy increases with age, and its presence is a risk factor for cardiovascular events and death. Recognizing the exact condition underlying LVH is a key step to provide an optimal medical management of those patients, including risk stratification, prognosis and treatment. By the use of multimodal imaging, by the appropriate use of genetics, and by considering clinical, electrical and biological red flags, the identification of the underlying disease becomes more and more achievable in the clinics, without the need for a myocardial biopsy. This review describes the recent diagnostic advances for the medical management of left ventricular hypertrophy.

摘要

左心室肥厚(LVH)定义为左心室质量增加。LVH可以是适应性的,与左心室压力或容量负荷增加有关,也可以与原发性心肌病有关,包括肌节、炎症或浸润性疾病。左心室肥厚的患病率随年龄增长而增加,其存在是心血管事件和死亡的危险因素。识别LVH的确切病因是为这些患者提供最佳医疗管理的关键步骤,包括风险分层、预后评估和治疗。通过使用多模态成像、合理运用遗传学,并考虑临床、电学和生物学警示信号,在临床上越来越能够识别潜在疾病,而无需进行心肌活检。本综述描述了左心室肥厚医疗管理方面的最新诊断进展。

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