Fekete P, Petrek J, Majmudar B, Someren A, Sandberg W
Arch Pathol Lab Med. 1987 May;111(5):427-32.
Data on clinical and pathologic features of tumors from 21 patients who had breast tumors compatible with juvenile (cellular) fibroadenomas (JCF) were reviewed. All patients were black females ranging in age at time of presentation from 10 to 39 years, with a median age of 15 years. Follow-up (median period, six years) was obtained for 20 patients. Patients were categorized into two groups; 13 had solitary lesions and eight had multiple and successive lesions. No histologic differences were observed between JCF occurring as solitary or multiple tumors or between lesions occurring in patients younger and older than age 20 years. The JCF was shown to be a fairly distinct clinicopathologic entity that characteristically occurred in adolescents, but which was occasionally seen in young adults. It had a benign course, characterized by synchronous and metachronous multicentricity, rather than local recurrence.
回顾了21例患有符合青少年（细胞性）纤维腺瘤（JCF）的乳腺肿瘤患者的肿瘤临床和病理特征数据。所有患者均为黑人女性，就诊时年龄在10至39岁之间，中位年龄为15岁。20例患者获得了随访（中位时间为6年）。患者被分为两组；13例有孤立性病变，8例有多发且连续的病变。在作为孤立性或多发性肿瘤出现的JCF之间，以及在20岁以下和20岁以上患者中出现的病变之间，未观察到组织学差异。JCF被证明是一种相当独特的临床病理实体，典型地发生于青少年，但偶尔也可见于年轻成年人。它具有良性病程，其特征为同时性和异时性多中心性，而非局部复发。
