Ozzello L, Gump F E
Surg Gynecol Obstet. 1985 Feb;160(2):99-104.
This study focuses upon 38 patients found to have unsuspected carcinomas or lobular neoplasia in fibroadenomatous tumors. Combining the pathologic and clinical features of these patients with those of 56 comparable instances reported upon in the literature, it becomes apparent that the biologic and clinical behavior of lobular neoplasia, intraductal carcinomas and invasive carcinomas is essentially the same regardless of whether the lesions arise in or outside a fibroadenoma. In addition, they are often a part of a multifocal malignant condition in the ipsilateral or contralateral breast. These patients, therefore, should be treated as if the carcinomas or lobular neoplasia arose in the usual setting.
本研究聚焦于38例在纤维腺瘤性肿瘤中发现有意外癌或小叶瘤变的患者。将这些患者的病理和临床特征与文献报道的56例类似病例相结合后发现，无论病变是发生在纤维腺瘤内还是纤维腺瘤外，小叶瘤变、导管内癌和浸润性癌的生物学行为和临床行为基本相同。此外，它们常是同侧或对侧乳房多灶性恶性病变的一部分。因此，这些患者应按照癌或小叶瘤变发生在通常情况下进行治疗。
