老年早期乳腺癌保乳手术后放疗的争议问题：一项系统综述
Controversial issues in radiotherapy after breast-conserving surgery for early breast cancer in older patients: a systematic review.
作者信息
Tang Liuwei, Matsushita Haruo, Jingu Keiichi
机构信息
Department of Radiation Oncology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-chou, Aoba-ku, Sendai, Japan.
出版信息
J Radiat Res. 2018 Nov 1;59(6):789-793. doi: 10.1093/jrr/rry071.
Abstract
Breast cancer is the most common malignant disease among older women, and the number of new older patients per year is increasing year by year. Radiotherapy has been confirmed as an important treatment after breast conservation for the reduction of local recurrence and mortality for all patients, including node-positive cases. However, there are fewer clinical trials evaluating the toxicity and benefits of radiotherapy for older patients. Whether radiotherapy can provide substantial benefit for older patients after breast-conserving surgery is controversial. This systematic review will focus on the key aspects of this controversial issue.
摘要
乳腺癌是老年女性中最常见的恶性疾病，每年新增老年患者的数量逐年增加。放射治疗已被确认为保乳术后的重要治疗手段，可降低包括淋巴结阳性病例在内的所有患者的局部复发率和死亡率。然而，评估放射治疗对老年患者毒性和益处的临床试验较少。保乳手术后放射治疗是否能为老年患者带来实质性益处存在争议。本系统评价将聚焦于这一争议问题的关键方面。
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