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针对一个由来已久的难题的实用近距离放射治疗解决方案。

Practical brachytherapy solutions to an age-old quandary.

作者信息

Thiruthaneeswaran N, Tharmalingam H, Hoskin P J

机构信息

Division of Cancer Sciences, The University of Manchester, Manchester, UK.

Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.

出版信息

Tech Innov Patient Support Radiat Oncol. 2020 Oct 26;16:39-47. doi: 10.1016/j.tipsro.2020.09.004. eCollection 2020 Dec.

Abstract

Cancer is predominantly a disease of the elderly and as population life expectancy increases, so will the incidence of malignant disease. Elderly patients often have other comorbidities and social complexities, increasing the support required to safely deliver all treatment modalities. Brachytherapy is a relatively simple technique by which radiation therapy can be delivered. It offers dosimetric advantages through a highly conformal dose distribution thereby limiting radiation exposure to normal tissues reducing toxicity. Requiring fewer hospital visits, it also offers practical and logistical advantages to the elderly population and in many cases can be performed without the need for general anaesthesia. In tumour streams where brachytherapy forms part of the curative management, it should not be omitted in elderly patients who are medically fit for treatment. In the palliative setting, brachytherapy often offers an excellent means for achieving either local tumour and/or symptom control and should be actively considered in the therapeutic armamentarium of the oncologist in this context.

摘要

癌症主要是一种老年疾病,随着人口预期寿命的增加,恶性疾病的发病率也会上升。老年患者往往还患有其他合并症和社会复杂性问题,这就增加了安全实施所有治疗方式所需的支持。近距离放射治疗是一种相对简单的放射治疗技术。它通过高度适形的剂量分布提供剂量学优势,从而限制对正常组织的辐射暴露,降低毒性。由于所需的医院就诊次数较少,它还为老年人群提供了实际和后勤方面的优势,并且在许多情况下无需全身麻醉即可进行。在近距离放射治疗作为根治性治疗一部分的肿瘤治疗流程中,对于身体状况适合治疗的老年患者,不应省略该治疗方法。在姑息治疗中,近距离放射治疗通常是实现局部肿瘤控制和/或症状控制的极佳手段,在这种情况下,肿瘤学家应在治疗手段中积极考虑采用该方法。

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