Baha Ayşe, Yıldırım Fatma, Köktürk Nurdan, Galata Züleyha, Akyürek Nalan, Demirci Nilgün Yılmaz, Türktaş Haluk
Department of Pulmonary Medicine, Ufuk University School of Medicine, Ankara, Turkey.
Clinic of Pulmonary Disease and Intensive Care Unit, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
Turk Thorac J. 2018 Sep 13;19(4):201-208. doi: 10.5152/TurkThoracJ.2018.18008. Print 2018 Oct.
Organizing pneumonia is an important disease that is associated with non-specific clinical findings and radiographic appearance. Our aim was to examine the clinical and radiological features, laboratory findings, diagnostic approach, and response to therapy in subjects with cryptogenic (COP) and secondary organizing pneumonia (SOP).
Patients' medical records were retrospectively reviewed between 2010 and 2016 in our hospital. We analyzed the symptoms, radiological features, pulmonary function tests, laboratory data, bronchoalveolar lavage findings, treatment, and prognosis.
Thirty-seven patients were diagnosed with COP and 19 patients with SOP. The most common causes of SOP were determined as rheumatologic diseases. The most common symptoms were cough (71.4%) and dyspnea (66.1%). Bilateral symmetrical consolidations were the most prominent radiological appearance in both COP and SOP. The general radiographic findings were not different in COP and SOP. However, pulmonary lesions were located rather in the central (p=0.023) and middle (p=0.001) zones in patients with SOP. Corticosteroid (CS) therapy was administered to 34 (60.7%) patients. Two patients showed deterioration despite CS therapy.
The clinical and radiographic findings, treatment response, prognosis were similar in patients with COP and SOP.
机化性肺炎是一种重要疾病，与非特异性临床症状和影像学表现相关。我们的目的是研究隐源性机化性肺炎（COP）和继发性机化性肺炎（SOP）患者的临床和放射学特征、实验室检查结果、诊断方法及治疗反应。
回顾性分析我院2010年至2016年期间患者的病历。我们分析了症状、放射学特征、肺功能检查、实验室数据、支气管肺泡灌洗结果、治疗及预后。
37例患者诊断为COP，19例患者诊断为SOP。SOP最常见的病因是风湿性疾病。最常见的症状是咳嗽（71.4%）和呼吸困难（66.1%）。双侧对称性实变是COP和SOP最突出的放射学表现。COP和SOP的一般放射学表现无差异。然而，SOP患者的肺部病变更多位于中央区（p=0.023）和中区（p=0.001）。34例（60.7%）患者接受了糖皮质激素（CS）治疗。2例患者尽管接受了CS治疗仍出现病情恶化。
COP和SOP患者的临床和影像学表现、治疗反应及预后相似。
