Radzikowska E, Roży A, Jaguś P, Wiatr E, Gawryluk D, Chorostowska-Wynimko J, Roszkowski-Śliż K
Third Department of Lung Diseases, National Tuberculosis and Lung Diseases Research Institute, 26 Płocka St, 01-138, Warsaw, Poland.
Department of Genetics and Clinical Immunology, National Tuberculosis and Lung Diseases Research Institute, 26 Płocka St, 01-138, Warsaw, Poland.
Adv Exp Med Biol. 2016;911:77-85. doi: 10.1007/5584_2016_223.
Cryptogenic organizing pneumonia (COP) is a distinct clinicopathological entity with unknown etiology. Inflammatory cytokines play a role in the development of the disease. The present study was performed to assess the correlation between concentrations of IL-1β, IL-6, IL-8, and TGF-β1 in the serum with response to clarithromycin (CAM) treatment in patients with COP. A total of 39 patients with COP were enrolled in to this study. An oral dose of 500 mg CAM was administered to all of the patients twice daily for 3 months. A complete response was noticed in 31 (80 %) of patients, and 8 (20 %) patients failed to respond to treatment. The concentration of cytokines were assessed by ELISAs before and after treatment. CAM treatment was associated with decreases in serum IL-6 (3.8 pg/mL [IQR 0.9-11.8] vs. 1.1 pg/mL [IQR 0.2-3.1]; p = 0.004), IL-8 (13.6 pg/mL [IQR 9.8-17.5] vs. 8.1 pg/mL [IQR 6.2-13.2]; p = 0.004), and TGF-β1 (37.1 ng/mL [IQR 31.7-46.2] vs. 25.7 ng/mL [IQR 22-41.7];p = 0.0001), which was particularly notable in the responders. We conclude that IL-6, IL-8, and TGF-β1 may play a role in the pathogenesis of COP, as their decreased concentrations were associated with a positive response to CAM treatment.
隐源性机化性肺炎（COP）是一种病因不明的独特临床病理实体。炎性细胞因子在该疾病的发生发展中起作用。本研究旨在评估COP患者血清中白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）和转化生长因子-β1（TGF-β1）浓度与对克拉霉素（CAM）治疗反应之间的相关性。本研究共纳入39例COP患者。所有患者口服500mg CAM，每日两次，共3个月。31例（80%）患者出现完全缓解，8例（20%）患者治疗无效。治疗前后通过酶联免疫吸附测定（ELISA）评估细胞因子浓度。CAM治疗与血清IL-6（3.8pg/mL[四分位间距0.9 - 11.8] vs. 1.1pg/mL[四分位间距0.2 - 3.1]；p = 0.004）、IL-8（13.6pg/mL[四分位间距9.8 - 17.5] vs. 8.1pg/mL[四分位间距6.2 - 13.2]；p = 0.004）和TGF-β1（37.1ng/mL[四分位间距31.7 - 46.2] vs. 25.7ng/mL[四分位间距22 - 41.7]；p = 0.0001）浓度降低相关，这在有反应者中尤为显著。我们得出结论，IL-6、IL-8和TGF-β1可能在COP的发病机制中起作用，因为它们浓度的降低与对CAM治疗的阳性反应相关。
