Brouwer Patrick A, Brinjikji Waleed, De Meyer Simon F
Neuroradiology Department, Neurointervention Section, Karolinska University Hospital, Eugeniavägen 3, Stockholm, 171 64 Solna, Sweden.
Department of Radiology, Mayo Clinic, 1216 2nd St SW, Rochester, MN 55902, USA; Department of Neurosurgery, Mayo Clinic, 1216 2nd St SW, Rochester, MN 55902, USA; Joint Department of Medical Imaging, Toronto Western Hospital, 399 Bathurst St, Toronto, ON M5T 2S8, Canada.
Neuroimaging Clin N Am. 2018 Nov;28(4):611-623. doi: 10.1016/j.nic.2018.06.005. Epub 2018 Sep 15.
Cerebral ischemic stroke treatment may change significantly now that clots are actually physically removed from the patient using thrombectomy. This allows for an analysis of the content of the clots as well as the correlation of the imaging findings and the clot behavior and morphology. This article illustrates how the interaction of different clots varies in the clinical setting and how analysis of clot composition, as well as the search for new pharmacologic targets, can lead to a better understanding of the pathophysiology and therapy resistance, in turn providing possibilities for a better approach in the treatment.
鉴于现在可通过血栓切除术实际从患者体内物理清除血栓，脑缺血性中风的治疗可能会发生显著变化。这使得能够对血栓的成分进行分析，以及对影像学检查结果与血栓行为和形态之间的相关性进行分析。本文阐述了不同血栓在临床环境中的相互作用如何不同，以及对血栓成分的分析以及寻找新的药理学靶点如何能够更好地理解病理生理学和治疗抵抗性，进而为更好的治疗方法提供可能性。
