Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
J Pharmacol Sci. 2018 Oct;138(2):155-159. doi: 10.1016/j.jphs.2018.06.003. Epub 2018 Jun 7.
We evaluated the anxiolytic effect of γ-oryzanol (GORZ) and elucidated the molecular mechanisms involved in its inhibition of behavioral test-induced anxiety. Behavioral tests were conducted on day 13, and mice were subjected to 30 min of acute restraint stress treatment (ARST) before sacrifice on day 16. In other group, behavioral tests were conducted on day 13 and 14 after ARST. 0.5% GORZ significantly weakened the effect of behavioral stress, but not the effect of strong ARST. GORZ downregulated ARST-induced cFos levels in the cerebral cortex. In conclusion, GORZ has potential ant-anxiety effect in the treatment of weak behavioral test-induced stress.
我们评估了γ-谷维素（GORZ）的抗焦虑作用，并阐明了其抑制行为测试诱导的焦虑的分子机制。行为测试在第 13 天进行，在第 16 天牺牲前对小鼠进行 30 分钟的急性束缚应激处理（ARST）。在其他组中，ARST 后在第 13 天和第 14 天进行行为测试。0.5%的 GORZ 显著减弱了行为应激的作用，但对强 ARST 没有作用。GORZ 下调了 ARST 诱导的大脑皮层中的 cFos 水平。总之，GORZ 在治疗弱行为测试诱导的应激方面具有潜在的抗焦虑作用。
