Aleĭnik S I, Stan E Ia, Chernikov M P
Biull Eksp Biol Med. 1987 Apr;103(4):390-2.
The influence of the peptide inhibiting gastric acid secretion and derived from kappa-casein on the levels of cAMP, cGMP and adenylate cyclase activity of rat gastric mucosa was studied. Intravenous peptide preparation administration failed to alter cyclic nucleotide levels. The revealed decrease of adenylate cyclase activity was due to the presence of calcium in the investigated peptide preparation. It was assumed that cyclase system of the rat gastric mucosa cells were not involved in the inhibition of gastric acid secretion by the peptide preparations under study.
研究了源自κ-酪蛋白的抑制胃酸分泌肽对大鼠胃黏膜中环磷酸腺苷（cAMP）、环磷酸鸟苷（cGMP）水平及腺苷酸环化酶活性的影响。静脉注射该肽制剂未能改变环核苷酸水平。所揭示的腺苷酸环化酶活性降低是由于所研究的肽制剂中存在钙。据推测，大鼠胃黏膜细胞的环化酶系统未参与所研究的肽制剂对胃酸分泌的抑制作用。
