Saito K, Saito A, Fu Y S, Smotkin D, Gupta J, Shah K
Cancer. 1987 Jun 15;59(12):2064-70. doi: 10.1002/1097-0142(19870615)59:12<2064::aid-cncr2820591217>3.0.co;2-7.
In this study of 101 cervical conization specimens, the location and the size of condyloma and intraepithelial neoplasia (dysplasia and carcinoma in situ) were mapped using the last endocervical gland as the marker for the original squamocolumnar junction. Condylomatous changes were identified in 85% of cervices affected by the intraepithelial neoplasia, and were in direct contact with 68% of intraepithelial neoplasms. The proximal location of intraepithelial neoplasia in relation to the condyloma can be explained by the occurrence of neoplasia just proximal to the condyloma and subsequent expansion of neoplasia towards the cervical canal. This study adds topographic evidence linking cervical condyloma to the development of intraepithelial neoplasia.
在这项对101例宫颈锥切标本的研究中，以最后一个宫颈管腺体作为原始鳞柱交界的标记，绘制尖锐湿疣和上皮内瘤变（发育异常和原位癌）的位置及大小。在85%受上皮内瘤变影响的宫颈中发现了湿疣样改变，且这些改变与68%的上皮内瘤变直接接触。上皮内瘤变相对于尖锐湿疣的近端位置可通过湿疣近端发生瘤变并随后向宫颈管扩展来解释。本研究增加了将宫颈尖锐湿疣与上皮内瘤变发展相联系的地形学证据。
