Pangalis G A, Yataganas X, Fessas P
J Clin Pathol. 1977 Sep;30(9):812-6. doi: 10.1136/jcp.30.9.812.
beta-Glucuronidase activity was semiquantitatively estimated in the cells of lymph node (LN) imprints from patients with Hodgkin's disease (HD), diffuse non-Hodgkin's lymphomas, chronic lymphocytic leukaemia (CLL), normal lymph nodes, and benign lymphadenopathies. In addition, in some of these cases beta-glucuronidase activity was semiquantitatively determined in peripheral blood smear lymphocytes. The beta-glucuronidase score (betaGS) was very low in the cells of the LN imprints from patients with diffuse non-Hodgkin's lymphomas. The LN lymphocytes of HD had a normal betaGS independently of the histological subtype of the disease, while in the LN imprint of CLL the enzyme activity was low, normal, or high. The betaGS of the lymphocytes in LN imprints of normal controls and HD were in general significantly lower compared with he lymphocytes of the peripheral blood smears in the same cases. The relation of our findings to the B and T cell origin of malignant lymphomas and chronic lymphocytic leukaemia is discussed.
对霍奇金病（HD）、弥漫性非霍奇金淋巴瘤、慢性淋巴细胞白血病（CLL）患者的淋巴结（LN）印片细胞、正常淋巴结及良性淋巴结病患者的淋巴结印片细胞进行β-葡萄糖醛酸酶活性的半定量评估。此外，在其中一些病例中，还对外周血涂片淋巴细胞进行了β-葡萄糖醛酸酶活性的半定量测定。弥漫性非霍奇金淋巴瘤患者的淋巴结印片细胞中的β-葡萄糖醛酸酶评分（βGS）非常低。HD患者的淋巴结淋巴细胞βGS正常，与疾病的组织学亚型无关，而CLL患者的淋巴结印片细胞中酶活性低、正常或高。正常对照和HD患者淋巴结印片淋巴细胞的βGS总体上显著低于同一病例外周血涂片淋巴细胞的βGS。讨论了我们的研究结果与恶性淋巴瘤和慢性淋巴细胞白血病的B细胞和T细胞起源的关系。
