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操作性学习与能量节约活动起搏治疗纤维肌痛综合征患者样本:一项初步随机对照试验。

Operant Learning Versus Energy Conservation Activity Pacing Treatments in a Sample of Patients With Fibromyalgia Syndrome: A Pilot Randomized Controlled Trial.

机构信息

Lawson Health Research Institute, London, Ontario, Canada; Department of Clinical Neurological Sciences, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Beryl & Richard Ivey Rheumatology Day Programs, St. Joseph's Health Care, London, Ontario, Canada.

Department of Rehabilitation Medicine, University of Washington, Seattle, Washington.

出版信息

J Pain. 2019 Apr;20(4):420-439. doi: 10.1016/j.jpain.2018.09.013. Epub 2018 Oct 13.

Abstract

This study's aim was to assess the efficacy of 2 forms of activity pacing in patients with fibromyalgia syndrome (FMS). Treatment-related changes in activity management patterns were also examined. Patients with FMS (n = 178) were randomly assigned to an operant learning (OL; delayed [n = 36] or immediate [n = 54] groups) or an energy conservation (EC; delayed [n = 35] or immediate [n = 53] groups) treatment condition. Of these, 32 OL and 37 EC patients completed treatment. Forty-three patients were allocated to the delayed treatment condition (control group). Repeated measures analyses of variance were used to examine the effects of OL and EC treatments on primary (average pain and usual fatigue), secondary (pain and fatigue interference, physical and psychological function, sleep quality, depressive symptoms, and anxiety symptoms), and tertiary (pain-related activity patterns) outcomes. Neither treatment was effective in reducing average pain or usual fatigue symptoms. Relative to EC, OL patients showed greater improvements in depressive symptoms, whereas nonsignificant trends (P values ranging between .05 and .06) were observed for pain interference, fatigue interference, and psychological function. Both treatments were associated with improvements in sleep quality and physical function, increases in pacing, and decreases in overdoing activity patterns. Reductions in activity avoidance were only found in OL. These findings suggest that OL may be more beneficial than EC and that it could potentially be viewed as an effective stand-alone activity pacing treatment for patients with FMS. Research to determine the extent to which these preliminary findings replicate is warranted. PERSPECTIVE: This article examines the efficacy of 2 forms of activity pacing in patients with fibromyalgia syndrome. The results suggest the possibility that operant learning may be more beneficial than energy conservation and could potentially be viewed as an effective stand-alone activity pacing treatment for patients with fibromyalgia syndrome.

摘要

本研究旨在评估两种活动调节形式在纤维肌痛综合征(FMS)患者中的疗效。还检查了与治疗相关的活动管理模式的变化。将 178 例 FMS 患者随机分配至操作性学习(OL;延迟组[n=36]或即刻组[n=54])或能量守恒(EC;延迟组[n=35]或即刻组[n=53])治疗条件。其中,32 例 OL 和 37 例 EC 患者完成了治疗。43 例患者被分配至延迟治疗条件(对照组)。采用重复测量方差分析来检验 OL 和 EC 治疗对主要(平均疼痛和一般疲劳)、次要(疼痛和疲劳干扰、身体和心理功能、睡眠质量、抑郁症状和焦虑症状)和三级(与疼痛相关的活动模式)结局的影响。两种治疗均不能有效减轻平均疼痛或一般疲劳症状。与 EC 相比,OL 患者的抑郁症状改善更大,而疼痛干扰、疲劳干扰和心理功能则出现了无显著差异的趋势(P 值在 0.05 至 0.06 之间)。两种治疗均与睡眠质量和身体功能的改善、活动节奏的增加以及过度活动模式的减少相关。仅在 OL 中发现活动回避减少。这些发现表明,OL 可能比 EC 更有效,并且它可能被视为 FMS 患者的一种有效的独立活动调节治疗。有必要进行研究以确定这些初步发现的复制程度。观点:本文检查了两种活动调节形式在纤维肌痛综合征患者中的疗效。结果表明,操作性学习可能比能量守恒更有效,并且可能被视为纤维肌痛综合征患者的一种有效的独立活动调节治疗。

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