Argiolas A, Melis M R, Fratta W, Mauri A, Gessa G L
Pharmacol Biochem Behav. 1987 Mar;26(3):503-7. doi: 10.1016/0091-3057(87)90156-0.
The effect of the intracerebroventricular (ICV) injection of ACTH 1-24 (1, 5 and 10 micrograms) or the subcutaneous administration of apomorphine (20 and 80 micrograms/kg SC) on spontaneous penile erection and yawning was studied in rats treated with monosodium glutamate (MSG), a treatment that depletes hypothalamic ACTH, alpha-MSH and endorphin-like peptides. Neonatal MSG treatment failed to antagonize either apomorphine- or ACTH-induced yawning in male and female rats, or to alter the number of penile erection episodes induced by the two substances in male rats. In contrast, hypophysectomy, that does not alter the concentration of hypothalamic ACTH and alpha-MSH, caused a marked prevention of apomorphine- and ACTH-induced responses, in agreement with previous studies. The results suggest that the integrity of opiomelanotropinergic neurons in the hypothalamus is not necessary for the induction of yawning and penile erection by ACTH-derived peptides, and that apomorphine and other dopamine agonists apparently do not induce penile erection and yawning by releasing an ACTH-derived peptide in brain.
在经谷氨酸单钠（MSG）处理的大鼠中，研究了脑室内（ICV）注射促肾上腺皮质激素1 - 24（1、5和10微克）或皮下注射阿扑吗啡（20和80微克/千克，皮下注射）对自发性阴茎勃起和打哈欠的影响。MSG处理会消耗下丘脑促肾上腺皮质激素、α-促黑素和内啡肽样肽。新生大鼠经MSG处理未能拮抗阿扑吗啡或促肾上腺皮质激素诱导的雄性和雌性大鼠打哈欠，也未改变两种物质诱导的雄性大鼠阴茎勃起次数。相比之下，垂体切除并不改变下丘脑促肾上腺皮质激素和α-促黑素的浓度，但与先前研究一致，它能显著抑制阿扑吗啡和促肾上腺皮质激素诱导的反应。结果表明，下丘脑阿片黑素细胞刺激素能神经元的完整性对于促肾上腺皮质激素衍生肽诱导打哈欠和阴茎勃起并非必要，并且阿扑吗啡和其他多巴胺激动剂显然不是通过在脑中释放促肾上腺皮质激素衍生肽来诱导阴茎勃起和打哈欠的。
