Galindo Tabitha, Reyna Jose, Weyer Andy
School of Physical Therapy and Athletic Training, Pacific University, Hillsboro, OR 97116, USA.
Biological Sciences Department, City College of San Francisco, San Francisco, CA 94112, USA.
Pharmaceuticals (Basel). 2018 Oct 15;11(4):105. doi: 10.3390/ph11040105.
Based on clinical and preclinical evidence, Transient Receptor Potential (TRP) channels have emerged as potential drug targets for the treatment of osteoarthritis, rheumatoid arthritis, and gout. This review summarizes the relevant data supporting a role for various TRP channels in arthritis pain and pathogenesis, as well as the current state of pharmacological efforts to ameliorate arthritis symptoms in patient populations.
基于临床和临床前证据，瞬时受体电位（TRP）通道已成为治疗骨关节炎、类风湿性关节炎和痛风的潜在药物靶点。本综述总结了支持各种TRP通道在关节炎疼痛和发病机制中作用的相关数据，以及在患者群体中改善关节炎症状的药理学研究现状。
