3-岩藻糖基化-N-乙酰乳糖胺碳水化合物决定簇在肾肿瘤中的表达

The expression of 3-fucosylated-N-acetyl lactosamine carbohydrate determinants in renal tumours.

作者信息

Fleming S, Brown G

出版信息

Histopathology. 1987 Feb;11(2):171-82. doi: 10.1111/j.1365-2559.1987.tb02620.x.

DOI:10.1111/j.1365-2559.1987.tb02620.x

Abstract

The distribution in renal tumours of 3-fucosyl-N-acetyl lactosamine has been studied by using the monoclonal antibodies AGF 4.36 and AGF 4.48 and immunoperoxidase methods on tissue sections. Seven of 19 nephroblastomas and 12 of 30 renal cell carcinomas contained the epitope. In nephroblastomas the epitope was found on the terminals of type B tubules in six cases and in one case on the type A or neoplastic tubules. In renal carcinoma the antigen was found on the surface of tumour cells. The results suggest that in kidneys bearing nephroblastomas ureteric bud elements may grow into the tumour from the adjacent kidney.

摘要

利用单克隆抗体AGF 4.36和AGF 4.48以及免疫过氧化物酶方法，对组织切片上肾肿瘤中3-岩藻糖基-N-乙酰乳糖胺的分布进行了研究。19例肾母细胞瘤中有7例、30例肾细胞癌中有12例含有该表位。在肾母细胞瘤中，6例在B型小管末端发现该表位，1例在A型或肿瘤性小管中发现。在肾细胞癌中，抗原在肿瘤细胞表面发现。结果表明，在患有肾母细胞瘤的肾脏中，输尿管芽成分可能从相邻肾脏长入肿瘤。