Liebert M, Jaffe R, Taylor R J, Ballou B T, Solter D, Hakala T R
Cancer. 1987 Apr 15;59(8):1404-8. doi: 10.1002/1097-0142(19870415)59:8<1404::aid-cncr2820590804>3.0.co;2-d.
Stage-specific embryonic antigen-1 (SSEA-1) was localized on paraffin embedded, formalin fixed specimens of human renal tumors by immunoperoxidase staining using a monoclonal antibody. Of 19 renal cell carcinoma (RCC) samples tested, 12 were positive for SSEA-1; SSEA-1 was also found on distinct elements in two samples of Wilms' tumor. No correlation was found between expression of SSEA-1, and RCC morphology or pattern of growth. Because SSEA-1 is found on proximal tubules in the normal kidney, these results support the hypothesis that RCC arises from the cells of the proximal tubule. Furthermore, since greater than 60% of the RCCs examined expressed SSEA-1, this antigen may prove to be a useful target for immunolocation or therapy of metastatic RCC.
通过使用单克隆抗体的免疫过氧化物酶染色，在福尔马林固定、石蜡包埋的人类肾肿瘤标本上定位了阶段特异性胚胎抗原-1（SSEA-1）。在检测的19个肾细胞癌（RCC）样本中，12个SSEA-1呈阳性；在两个肾母细胞瘤样本的不同成分中也发现了SSEA-1。未发现SSEA-1的表达与RCC形态或生长模式之间存在相关性。由于在正常肾脏的近端小管中发现了SSEA-1，这些结果支持了RCC起源于近端小管细胞的假说。此外，由于超过60%的检测RCC表达SSEA-1，这种抗原可能被证明是转移性RCC免疫定位或治疗的有用靶点。
