Atherton S S, Pesicka G A, Streilein J W
Invest Ophthalmol Vis Sci. 1987 May;28(5):859-66.
Following anterior chamber inoculation of herpes simplex virus type 1 (HSV-1) into one eye of adult, immunocompetent BALB/c mice, an interesting pattern of ocular pathology and systemic immune responses emerges, characterized by destruction of the contralateral retina with sparing of the ipsilateral retina; and impairment of delayed hypersensitivity (DH) accompanied by intact humoral immunity to the virus. Experiments using animals inoculated via the intravitreal route revealed a different pattern of retinitis in the inoculated and in the uninoculated fellow eye following intravitreal inoculation of HSV-1. The retinitis in the inoculated eye results in localized, focal necrosis with concomitant preservation of the retinal architecture in areas juxtaposed to those in which retinal destruction occurs. The retinitis in the uninoculated contralateral eye is characterized by pan-retinal inflammation and subsequent loss of the architecture of the entire retina. Intravitreally inoculated animals exhibited virus-specific impairment of DH responses to HSV-1 but were capable of producing anti-HSV-1 neutralizing antibody. Impairment of DH response after inoculation of live HSV-1 suggests that intraocular processing of viral antigens occurs such that processed antigens are released systemically in a soluble form.
将1型单纯疱疹病毒（HSV-1）接种到成年、免疫功能正常的BALB/c小鼠的一只眼睛的前房后，出现了一种有趣的眼部病理和全身免疫反应模式，其特征是对侧视网膜遭到破坏，而同侧视网膜未受影响；迟发型超敏反应（DH）受损，同时对该病毒的体液免疫保持完好。通过玻璃体内途径接种动物的实验显示，在玻璃体内接种HSV-1后，接种眼和未接种的另一只眼出现了不同的视网膜炎模式。接种眼中的视网膜炎导致局部、灶性坏死，同时在与发生视网膜破坏的区域相邻的区域保留视网膜结构。未接种的对侧眼中的视网膜炎的特征是全视网膜炎症以及随后整个视网膜结构的丧失。玻璃体内接种的动物对HSV-1的DH反应出现病毒特异性受损，但能够产生抗HSV-1中和抗体。接种活HSV-1后DH反应受损表明，病毒抗原在眼内进行了加工处理，从而使加工后的抗原以可溶形式全身释放。
