在水中用碘化亚铜催化 2-卤代苯胺、氨和醛的三组分反应合成苯并咪唑。
Synthesis of benzimidazoles by CuI-catalyzed three-component reaction of 2-haloaniline, ammonia and aldehyde in water.
机构信息
College of Pharmacy, Fujian Medical University, Fuzhou 350004, China.
出版信息
Org Biomol Chem. 2018 Nov 7;16(43):8090-8094. doi: 10.1039/c8ob02172d.
PMID:30328461
Abstract
An efficient copper-catalyzed three-component reaction of 2-haloaniline, ammonia and aldehyde for the synthesis of benzimidazoles with 1,10-phenanthroline as the ligand has been developed. A variety of substituted benzimidazole derivatives can be obtained in yields up to 95%.
摘要
开发了一种高效的铜催化 2-卤代苯胺、氨和醛的三组分反应，以 1,10-菲啰啉作为配体合成苯并咪唑。各种取代的苯并咪唑衍生物可以高达 95%的产率得到。
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