Chemistry Division, School of Science and Technology, University of Camerino, 62032 Camerino, Italy.
Laboratori Alchemia Srl, Via San Faustino, 20134 Milano, Italy.
Molecules. 2021 Apr 29;26(9):2620. doi: 10.3390/molecules26092620.
The outbreak of SARS-CoV-2 has drastically changed our everyday life and the life of scientists from all over the world. In the last year, the scientific community has faced this worldwide threat using any tool available in order to find an effective response. The recent formulation, production, and ongoing administration of vaccines represent a starting point in the battle against SARS-CoV-2, but they cannot be the only aid available. In this regard, the use of drugs capable to mitigate and fight the virus is a crucial aspect of the pharmacological strategy. Among the plethora of approved drugs, a consistent element is a heterocyclic framework inside its skeleton. Heterocycles have played a pivotal role for decades in the pharmaceutical industry due to their high bioactivity derived from anticancer, antiviral, and anti-inflammatory capabilities. In this context, the development of new performing and sustainable synthetic strategies to obtain heterocyclic molecules has become a key focus of scientists. In this review, we present the recent trends in metal-promoted heterocyclization, and we focus our attention on the construction of heterocycles associated with the skeleton of drugs targeting SARS-CoV-2 coronavirus.
SARS-CoV-2 的爆发极大地改变了我们的日常生活和全世界科学家的生活。在过去的一年中，科学界利用一切可用的工具应对这一全球性威胁，以寻找有效的应对措施。最近疫苗的配方、生产和正在进行的管理代表了对抗 SARS-CoV-2 的一个起点，但它们不能是唯一可用的手段。在这方面，使用能够减轻和对抗病毒的药物是药理学策略的一个关键方面。在众多已批准的药物中，有一个一致的元素是其骨架内的杂环框架。由于具有抗癌、抗病毒和抗炎能力，杂环化合物几十年来在制药行业中发挥了至关重要的作用。在这种情况下，开发新的、性能更高且可持续的合成策略来获得杂环分子已成为科学家们的一个重点关注领域。在这篇综述中，我们介绍了金属促进杂环化的最新趋势，并将重点放在与针对 SARS-CoV-2 冠状病毒的药物骨架相关的杂环构建上。
