College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
J Org Chem. 2011 Jan 7;76(1):223-8. doi: 10.1021/jo102060j. Epub 2010 Dec 10.
An efficient tandem route to the synthesis of iodoisoquinoline-fused benzimidazole derivatives including an iodocyclization strategy has been developed. In the presence of CuI, a variety of 2-ethynylbenzaldehydes underwent the tandem reaction with benzenediamines and iodine to afford the corresponding iodoisoquinoline-fused benzimidazoles in moderate to good yields.
开发了一种高效的串联途径来合成碘异喹啉并苯并咪唑衍生物，包括碘环化策略。在 CuI 的存在下，各种 2-乙炔基苯甲醛与苯二胺和碘进行串联反应，以中等至良好的收率得到相应的碘异喹啉并苯并咪唑。
