Yovell Y, Dudai Y
Isr J Med Sci. 1987 Jan-Feb;23(1-2):49-60.
Two experimental approaches--the cellular and the neurogenetic--to the study of molecular mechanisms of elementary memory implicate the cyclic AMP cascade in general, and adenylate cyclase in particular, in the processes of acquisition and short-term memory. Models of learning and memory should account for four basic phenomena: persistence of memory, stimulus convergence, temporal specificity and memory decay. These phenomena thus place constraints on the structure and operation of any postulated memory apparatus. The relevant experimental data derived from the study of memory mutants in Drosophila and of the gill and siphon withdrawal reflex in Aplysia are discussed and analyzed in light of the above mentioned constraints.
研究基本记忆分子机制的两种实验方法——细胞层面的和神经遗传学层面的——表明，一般而言环磷酸腺苷（cAMP）级联反应，尤其是腺苷酸环化酶，在记忆获取和短期记忆过程中发挥作用。学习和记忆模型应解释四种基本现象：记忆持久性、刺激汇聚、时间特异性和记忆衰退。因此，这些现象对任何假定的记忆机制的结构和运作都构成了限制。我们根据上述限制条件，对从果蝇记忆突变体研究以及海兔鳃和虹吸管收缩反射研究中获得的相关实验数据进行了讨论和分析。
