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手术切除的 pT1-2N0M0 期小细胞肺癌患者是否需要预防性颅脑照射?

Is prophylactic cranial irradiation necessary in individuals suffering from surgically resected pT1-2N0M0 small cell lung cancer?

机构信息

Zhejiang Key Laboratory of Diagnosis & Treatment Technology on Thoracic Oncology (lung and esophagus), Zhejiang Cancer Hospital, Hangzhou, 310022, People's Republic of China.

出版信息

Ir J Med Sci. 2019 Aug;188(3):761-764. doi: 10.1007/s11845-018-1912-0. Epub 2018 Oct 17.

DOI:10.1007/s11845-018-1912-0
PMID:30328575
Abstract

Adjuvant chemotherapeutics and prophylactic cranial irradiation (PCI) are both recommended in the National Comprehensive Cancer Network (NCCN) guidelines for treating individuals suffering from surgically resected pT1-2N0M0 small cell lung cancer (SCLC). Whether adjuvant chemotherapy combined with PCI is superior to adjuvant chemotherapy alone in these patients is largely unknown. PCI may therefore be with uncertain effects in surgically resected pT1-2N0M0 SCLC.

摘要

辅助化疗和预防性颅脑照射(PCI)均被推荐用于治疗手术切除的 pT1-2N0M0 小细胞肺癌(SCLC)患者的国家综合癌症网络(NCCN)指南中。辅助化疗联合 PCI 是否优于单纯辅助化疗,目前在这些患者中还知之甚少。因此,PCI 可能对手术切除的 pT1-2N0M0 SCLC 疗效不确定。

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本文引用的文献

1
Prophylactic Cranial Irradiation for Small Cell Lung Cancer: New Insights.小细胞肺癌的预防性颅脑照射:新见解
Int J Radiat Oncol Biol Phys. 2017 Sep 1;99(1):3-5. doi: 10.1016/j.ijrobp.2017.05.006. Epub 2017 Aug 7.
2
Patterns of failure in limited-stage small cell lung cancer: Implications of TNM stage for prophylactic cranial irradiation.局限期小细胞肺癌的失败模式:TNM分期对预防性颅脑照射的影响
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Outcomes of Stereotactic Body Radiotherapy for T1-T2N0 Small Cell Carcinoma According to Addition of Chemotherapy and Prophylactic Cranial Irradiation: A Multicenter Analysis.
根据是否加用化疗和预防性颅脑照射,立体定向体部放疗治疗 T1-T2N0 小细胞肺癌的结果:一项多中心分析。
Clin Lung Cancer. 2017 Nov;18(6):675-681.e1. doi: 10.1016/j.cllc.2017.03.009. Epub 2017 Mar 16.
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Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial.广泛期小细胞肺癌患者预防性颅脑照射与观察的比较:一项多中心、随机、开放标签、3 期临床试验。
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Risk factors for brain metastases after prophylactic cranial irradiation in small cell lung cancer.预防性全脑照射治疗小细胞肺癌后脑转移的危险因素。
Sci Rep. 2017 Feb 16;7:42743. doi: 10.1038/srep42743.
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Multi-Institutional Experience of Stereotactic Ablative Radiation Therapy for Stage I Small Cell Lung Cancer.立体定向消融放疗治疗Ⅰ期小细胞肺癌的多机构经验
Int J Radiat Oncol Biol Phys. 2017 Feb 1;97(2):362-371. doi: 10.1016/j.ijrobp.2016.10.041. Epub 2016 Nov 2.
7
Prophylactic Cranial Irradiation for Patients with Surgically Resected Small Cell Lung Cancer.手术切除的小细胞肺癌患者的预防性颅脑照射。
J Thorac Oncol. 2017 Feb;12(2):347-353. doi: 10.1016/j.jtho.2016.09.133. Epub 2016 Oct 7.
8
Role of Adjuvant Therapy in a Population-Based Cohort of Patients With Early-Stage Small-Cell Lung Cancer.辅助治疗在基于人群的早期小细胞肺癌患者队列中的作用。
J Clin Oncol. 2016 Apr 1;34(10):1057-64. doi: 10.1200/JCO.2015.63.8171. Epub 2016 Jan 19.
9
The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer.IASLC 肺癌分期项目:对即将发布的(第八版)肺癌 TNM 分类中 TNM 分期分组的修订建议。
J Thorac Oncol. 2016 Jan;11(1):39-51. doi: 10.1016/j.jtho.2015.09.009.
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Lung Cancer. 2015 Dec;90(3):548-53. doi: 10.1016/j.lungcan.2015.10.010. Epub 2015 Oct 14.