Glaninger J
Aktuelle Gerontol. 1978 Sep;8(9):493-502.
Each stage of life is characterized by the prevalence of certain affections; among others, inflammatory diseases of the ear, nose and throat are frequent in old age. Therefore, specific problems of chemotherapy in old age are dealt with in general terms in the introduction, with special stress being placed on the functions of individual organs, mainly of the kidneys, and on questions of disturbed absorption. Inflammations caused by streptococci, requiring at least ten days of antibiotic treatment, always deserve particular attention, and so do staphyloccocal diseases, requiring the selective administration of semi-synthetic pencillines (sioxazol preparations). Penicillin is still the first choice among all antibiotics, penicillin substitutes, to be used in case of allergies, are listed according to their order of value. As anaerobic germs may also be present in the ENT area, the effective modern therapy by means of special antibiotics is also referred to. Finally, due consideration is given to local antibiotic therapy, with an emphasis on the ototoxicity of chemotherapeutical agents, such as amino-glycosides.
生命的每个阶段都有特定疾病的流行特征；其中，耳鼻喉的炎症性疾病在老年时期较为常见。因此，在引言部分将从总体上探讨老年化疗的具体问题，特别强调各个器官的功能，主要是肾脏的功能，以及吸收障碍问题。由链球菌引起的炎症，至少需要十天的抗生素治疗，始终值得特别关注，葡萄球菌疾病也是如此，这类疾病需要选择性地使用半合成青霉素（恶唑类制剂）。在所有抗生素中，青霉素仍然是首选，若有过敏情况，则按照价值顺序列出可用的青霉素替代品。由于耳鼻喉区域也可能存在厌氧菌，因此也会提及使用特殊抗生素的有效现代疗法。最后，充分考虑了局部抗生素治疗，重点关注化疗药物如氨基糖苷类的耳毒性。
