Mankovski N B, Boutenko G M, Vainstock A B, Zaitchenko A P, Mints A J
Aktuelle Gerontol. 1978 Sep;8(9):487-92.
Studies were undertaken on the immune reactions in aging at cerebral atherosclerosis and parkinsonism. With age a number of changes occurred, which were characterized by a decrease in specific and non-specific immunity, against the background of which the autoimmune reactions were developing. There was an increase in the frequency of the detection of antibodies to antigens of the brain as well as in those of the aorta, heart, liver and pancreatic gland. The "peak" of autoimmune reactions was registered at 65 years in men and 75 years in women. There were lymphocytes in the peripheral blood, which together with homologic antigens inhibited the migration of macrophages. In subjects aged 90 years and over the autoantibodies occurred in a lower percent of cases as compared with the subjects aged 60--74. In subjects aged 45--55 with cerebral atherosclerosis the indices under study appeared to be close to those in healthy persons aged 60--74. Still more marked immunological shifts were found in patients with parkinsonism. The findings may suggest a certain role of the autoimmune mechanisms in pathogenesis of some forms of nervous pathology at late stages of ontogenesis and atherosclerosis.
针对脑动脉粥样硬化和帕金森病衰老过程中的免疫反应进行了研究。随着年龄增长，出现了许多变化，其特征是特异性和非特异性免疫下降，在此背景下自身免疫反应不断发展。检测到针对脑抗原以及主动脉、心脏、肝脏和胰腺抗原的抗体频率增加。自身免疫反应的“峰值”在男性为65岁，女性为75岁。外周血中存在淋巴细胞，其与同源抗原一起抑制巨噬细胞的迁移。与60 - 74岁的受试者相比，90岁及以上受试者中自身抗体出现的病例百分比更低。在患有脑动脉粥样硬化的45 - 55岁受试者中，所研究的指标似乎与60 - 74岁健康人的指标相近。在帕金森病患者中发现了更为明显的免疫变化。这些发现可能表明自身免疫机制在个体发育后期和动脉粥样硬化某些形式神经病理学发病机制中具有一定作用。
