Kelly P J, Daumas-Duport C, Kispert D B, Kall B A, Scheithauer B W, Illig J J
J Neurosurg. 1987 Jun;66(6):865-74. doi: 10.3171/jns.1987.66.6.0865.
Forty patients with previously untreated intracranial glial neoplasms underwent stereotaxic serial biopsies assisted by computerized tomography (CT) and magnetic resonance imaging (MRI). Tumor volumes defined by computer reconstruction of contrast enhancement and low-attenuation boundaries on CT and T1 and T2 prolongation on MRI revealed that tumor volumes defined by T2-weighted MRI scans were larger than those defined by low-attenuation or contrast enhancement on CT scans. Histological analysis of 195 biopsy specimens obtained from various locations within the volumes defined by CT and MRI revealed that: contrast enhancement most often corresponded to tumor tissue without intervening parenchyma; hypodensity corresponded to parenchyma infiltrated by isolated tumor cells or in some instances to tumor tissue in low-grade gliomas or to simple edema; and isolated tumor cell infiltration extended at least as far as T2 prolongation on magnetic resonance images. This information may be useful in planning surgical procedures and radiation therapy in patients with intracranial glial neoplasms.
40例未经治疗的颅内胶质肿瘤患者接受了计算机断层扫描（CT）和磁共振成像（MRI）辅助的立体定向系列活检。通过计算机重建CT上的对比增强和低衰减边界以及MRI上的T1和T2延长来定义肿瘤体积，结果显示，T2加权MRI扫描所定义的肿瘤体积大于CT扫描上低衰减或对比增强所定义的肿瘤体积。对从CT和MRI所定义体积内的不同位置获取的195份活检标本进行组织学分析发现：对比增强最常对应于无间质实质的肿瘤组织；低密度对应于被孤立肿瘤细胞浸润的实质，或在某些情况下对应于低级别胶质瘤中的肿瘤组织或单纯水肿；孤立的肿瘤细胞浸润在磁共振图像上至少延伸至T2延长处。这些信息可能有助于颅内胶质肿瘤患者手术和放疗方案的制定。
