Hantraye P, Mazière B, Mazière M, Fukuda H, Naquet R
J Physiol (Paris). 1986;81(4):278-82.
Using Positron Emission Tomography (PET) and specific radioligands, dopaminergic D2 (DA-D2 receptors) and benzodiazepine receptors (BZ-receptors) were studied in living animals during normal and pathological conditions. In vivo characterization of both receptors was performed using two highly specific antagonists namely: 11C-Ro 15 1788 for BZ-receptors and 76 Br-Bromospiperone for DA-D2 receptors. Changes in 11c-Ro 15 1788 specific binding to BZ-receptors were observed during convulsive seizures. After MPTP treatment, a decrease in the 76 Br-Bromospiperone striatal specific binding was observed, correlated with the establishment of a Parkinson-like syndrome.
利用正电子发射断层扫描（PET）和特定放射性配体，在正常和病理条件下对活体动物的多巴胺能D2（DA-D2受体）和苯二氮䓬受体（BZ受体）进行了研究。使用两种高度特异性拮抗剂对两种受体进行体内表征，即：用于BZ受体的11C-Ro 15 1788和用于DA-D2受体的76Br-溴螺哌酮。在惊厥发作期间观察到11C-Ro 15 1788与BZ受体特异性结合的变化。MPTP处理后，观察到76Br-溴螺哌酮纹状体特异性结合减少，这与帕金森样综合征的形成相关。
