a Laboratório de Interação celular e molecular, Departamento de Biologia Celular e Molecular , Universidade Federal Fluminense, Rua Outeiro São João Batista , Rio de Janeiro , Brazil.
b Fundação Oswaldo Cruz , Laboratório de Ultraestrutura Celular , Rio de Janeiro , Brazil.
J Drug Target. 2019 Aug;27(7):767-779. doi: 10.1080/1061186X.2018.1536982. Epub 2018 Oct 31.
Neglected tropical diseases caused by protozoan parasites affect the life of millions of people worldwide, causing mortality, morbidity and high economic and social burden. The search for new drug targets and therapeutic strategies to fight these pathogens are necessary, since many current drugs have limited effects, cause severe side effects and their use has resulted in pathogen resistance. Heme (iron protoporphyrin IX) is a ubiquitous molecule important in many biological processes, including the homeostasis, growth and development of human pathogens such as trypanosomatids (, and spp.) and spp. In this review, several chemotherapy approaches and strategies are discussed that target heme transport, catabolism, crystallization and hemeproteins.
被忽视的热带病由原生动物寄生虫引起，影响着全球数百万人的生活，导致死亡率、发病率以及高经济和社会负担。寻找新的药物靶点和治疗策略来对抗这些病原体是必要的，因为许多现有药物的效果有限，会引起严重的副作用，并且其使用导致了病原体的耐药性。血红素（铁原卟啉 IX）是一种普遍存在的分子，在许多生物过程中都很重要，包括人体病原体（如 、 和 spp.）和 spp.的内稳态、生长和发育。在这篇综述中，讨论了几种针对血红素运输、分解代谢、结晶和血红素蛋白的化疗方法和策略。
