病毒内部序列对逆转录病毒载体效用的影响。
Effect of internal viral sequences on the utility of retroviral vectors.
作者信息
Armentano D, Yu S F, Kantoff P W, von Ruden T, Anderson W F, Gilboa E
出版信息
J Virol. 1987 May;61(5):1647-50. doi: 10.1128/JVI.61.5.1647-1650.1987.
Abstract
Expression of the human ADA cDNA encoded by the Moloney murine leukemia virus spliced RNA form is enhanced by intron-contained sequences. The presence of sequences corresponding to the viral gag gene in a Moloney murine leukemia virus-based vector results in the generation of 10- to 40-fold higher titers of virus.
摘要
莫洛尼鼠白血病病毒剪接RNA形式编码的人ADA cDNA的表达通过含内含子的序列得到增强。在基于莫洛尼鼠白血病病毒的载体中存在与病毒gag基因对应的序列会导致产生的病毒滴度提高10至40倍。
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