Public Health, Department of Social Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.
Department of Public Health and Preventive Medicine, Faculty of Medicine, Minia University, Minia, Egypt.
Hypertens Res. 2018 Dec;41(12):1054-1062. doi: 10.1038/s41440-018-0106-5. Epub 2018 Oct 17.
This study aimed to assess the association of cigarette smoking with radial augmentation index among the Asian general population. We conducted a cross-sectional population-based study including 1593 men and 2671 women aged 40-79 years. Smoking status was ascertained through interviews, and the number of pack-years was calculated. The radial augmentation index was defined as the ratio of central pulse pressure to brachial pulse pressure, as measured using an automated tonometer: the HEM-9000AI (Omron Healthcare co., Kyoto, Japan). There was a higher prevalence of an increased radial augmentation index among current male smokers who smoked ≥ 30 cigarettes/day and all female smokers than among never smokers. After adjusting for known risk factors of atherosclerosis, the multivariable odds ratio (OR) [95% confidence interval (CI)] for a high radial augmentation index for current male smokers who smoked ≥30 cigarettes/day compared with never smokers was 1.9 (1.1-3.4). The multivariable OR (95% CI) for a high radial augmentation index for former female smokers and current female smokers compared with never smokers was 1.8 (1.2-2.7) and 2.5 (1.6-3.9), respectively. Moreover, smoking pack-years was positively associated with a high radial augmentation index in both sexes. There were no relationship between smoking status and high central or brachial pulse pressures among subjects of either sex. In conclusion, cigarette smoking and cumulative smoking exposure were positively associated with an increased radial augmentation index in men who smoked heavily and in women.
本研究旨在评估在亚洲普通人群中，吸烟与桡动脉增强指数之间的关联。我们进行了一项横断面的基于人群的研究，纳入了 1593 名男性和 2671 名年龄在 40-79 岁的女性。通过访谈确定吸烟状况，并计算吸烟包年数。桡动脉增强指数定义为中心脉压与肱动脉脉压的比值，使用自动血压计（日本京都欧姆龙医疗保健公司的 HEM-9000AI）测量。与从不吸烟者相比，目前每天吸烟≥30 支的男性吸烟者和所有女性吸烟者中，桡动脉增强指数升高的比例更高。在调整了动脉粥样硬化的已知危险因素后，与从不吸烟者相比，目前每天吸烟≥30 支的男性吸烟者发生高桡动脉增强指数的多变量比值比（OR）[95%置信区间（CI）]为 1.9（1.1-3.4）。与从不吸烟者相比，曾经吸烟的女性和当前吸烟的女性发生高桡动脉增强指数的多变量 OR（95%CI）分别为 1.8（1.2-2.7）和 2.5（1.6-3.9）。此外，吸烟包年数与两性的高桡动脉增强指数呈正相关。在男性和女性中，吸烟状况与高中心或肱动脉脉压之间均无关系。总之，在重度吸烟的男性和女性中，吸烟和累积吸烟暴露与桡动脉增强指数的增加呈正相关。
