吸烟者动脉僵硬度和动脉年龄的性别差异
Gender Differences of Arterial Stiffness and Arterial Age in Smokers.
作者信息
Mozos Ioana, Maidana Jean Paul, Stoian Dana, Stehlik Milan
机构信息
Department of Functional Sciences, "Victor Babes" University of Medicine and Pharmacy, 300173 Timisoara, Romania.
Center for Translational Research and Systems Medicine, "Victor Babes" University of Medicine and Pharmacy, 300173 Timisoara, Romania.
出版信息
Int J Environ Res Public Health. 2017 May 26;14(6):565. doi: 10.3390/ijerph14060565.
The present study aimed to find gender differences for arterial stiffness and arterial aging in smokers. A total of 147 smokers (71 male and 76 female, matched for age) were explored using an Arteriograph in a cross-sectional survey. Pulse wave velocity (PWV), arterial age (AA), brachial and aortic augmentation index (AixBrach, AixAo), and blood pressure variables were assessed. Data about smoking intensity, such as the number of cigarettes smoked daily, smoking period, and smoking pack years (SPY) were used. No significant differences were found for PWV, AA, AixBrach and AixAo. Significant correlations were found between SPY and PWV, augmentation indices, and AA, respectively. The cut-off values for SPY were higher for an increased arterial stiffness in male compared to female smokers (18.5 and 7.5 pack year, respectively). SPY is significantly associated with an increased arterial stiffness in smokers regardless of gender, and with an increased SBPAo only in female smokers. The results of our study indicate gender differences for arterial stiffness and arterial age in smokers.
本研究旨在探寻吸烟者动脉僵硬度和动脉老化的性别差异。在一项横断面调查中，使用动脉造影仪对总共147名吸烟者（71名男性和76名女性，年龄匹配）进行了研究。评估了脉搏波速度（PWV）、动脉年龄（AA）、肱动脉和主动脉增强指数（AixBrach、AixAo）以及血压变量。使用了关于吸烟强度的数据，如每日吸烟数量、吸烟时长和吸烟包年数（SPY）。未发现PWV、AA、AixBrach和AixAo存在显著差异。分别发现SPY与PWV、增强指数和AA之间存在显著相关性。男性吸烟者与女性吸烟者相比，动脉僵硬度增加时SPY的临界值更高（分别为18.5和7.5包年）。无论性别，SPY均与吸烟者动脉僵硬度增加显著相关，且仅在女性吸烟者中与收缩期主动脉压升高相关。我们的研究结果表明吸烟者在动脉僵硬度和动脉年龄方面存在性别差异。
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