Zhang Xue, Gao Fei, Wang Dongdong, Li Chao, Fu Yi, He Wei, Zhang Jianmin
Department of Immunology, Research Center on Pediatric Development and Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing, China.
Front Neurol. 2018 Oct 2;9:809. doi: 10.3389/fneur.2018.00809. eCollection 2018.
Tau protein-a member of the microtubule-associated protein family-is a key protein involved in many neurodegenerative diseases. Tau pathology in neurodegenerative diseases is characterized by pathological tau aggregation in neurofibrillary tangles (NFTs). Diseases with this typical pathological feature are called tauopathies. Parkinson's disease (PD) was not initially considered to be a typical tauopathy. However, recent studies have demonstrated increasing evidence of tau pathology in PD. A genome-wide association (GWA) study indicated a potential association between tauopathy and sporadic PD. The aggregation and deposition of tau were also observed in ~50% of PD brains, and it seems to be transported from neuron to neuron. The aggregation of NFTs, the abnormal hyperphosphorylation of tau protein, and the interaction between tau and alpha-synuclein may all contribute to the cell death and poor axonal transport observed in PD and Parkinsonism.
tau蛋白——微管相关蛋白家族的一员——是一种涉及多种神经退行性疾病的关键蛋白。神经退行性疾病中的tau病理特征是神经原纤维缠结（NFTs）中病理性tau聚集。具有这种典型病理特征的疾病被称为tau蛋白病。帕金森病（PD）最初并不被认为是典型的tau蛋白病。然而，最近的研究表明帕金森病中tau病理的证据越来越多。一项全基因组关联（GWA）研究表明tau蛋白病与散发性帕金森病之间存在潜在关联。在约50%的帕金森病患者大脑中也观察到了tau的聚集和沉积，并且它似乎在神经元之间传递。NFTs的聚集、tau蛋白的异常过度磷酸化以及tau与α-突触核蛋白之间的相互作用可能都导致了帕金森病和帕金森综合征中观察到的细胞死亡和轴突运输障碍。
