Benmarce Meryem, Henriksen Kim, Karsdal Morten, Holm Nielsen Signe
Nordic Bioscience, Herlev, Denmark.
Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.
Front Neurol. 2025 Apr 30;16:1566228. doi: 10.3389/fneur.2025.1566228. eCollection 2025.
Tau has shown to be associated with neurodegenerative diseases. In this exploratory study, we investigated the utility of blood-based biomarkers measuring Tau-C, Tau-A, and C1M in Parkinson's disease (PD) to explore their potential as diagnostic biomarkers in two independent cohorts (TAU-C and TAU-A). We found them to discriminate between healthy donors and PD individuals (all < 0.001), with Tau-C showing the best diagnostic discrepancy (AUROC = 0.97). Therefore, Tau-C, Tau-A, and C1M may be biomarkers for PD diagnosis.
已证明tau与神经退行性疾病有关。在这项探索性研究中，我们调查了在帕金森病（PD）中测量Tau-C、Tau-A和C1M的血液生物标志物的效用，以在两个独立队列（TAU-C和TAU-A）中探索它们作为诊断生物标志物的潜力。我们发现它们能够区分健康供体和PD患者（所有P值均<0.001），其中Tau-C显示出最佳的诊断差异（曲线下面积[AUC]=0.97）。因此，Tau-C、Tau-A和C1M可能是PD诊断的生物标志物。
