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Implications of MicroRNAs in the Treatment of Gefitinib-Resistant Non-Small Cell Lung Cancer.miRNAs 在吉非替尼耐药非小细胞肺癌治疗中的意义
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Reduced PDCD4 Expression Promotes Cell Growth Through PI3K/Akt Signaling in Non-Small Cell Lung Cancer.PDCD4表达降低通过PI3K/Akt信号通路促进非小细胞肺癌细胞生长。
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A Randomized Phase 2 Study Comparing 2 Stereotactic Body Radiation Therapy Schedules for Medically Inoperable Patients With Stage I Peripheral Non-Small Cell Lung Cancer: NRG Oncology RTOG 0915 (NCCTG N0927).一项随机2期研究，比较两种立体定向体部放射治疗方案用于无法进行手术的I期外周型非小细胞肺癌患者：NRG肿瘤学RTOG 0915（NCCTG N0927）
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微小RNA-133a通过AKT/ERK信号通路下调人非小细胞肺癌细胞中表皮生长因子受体（EGFR）的表达。

MicroRNA-133a downregulated EGFR expression in human non-small cell lung cancer cells via AKT/ERK signaling.

作者信息

Guo Nannan, Zhao Yingnan, Zhang Wen, Li Shaojun, Li Shanshan, Yu Jianqi

机构信息

Department of Cardiothoracic Surgery, The First Affiliated Hospital of General Hospital of The Chinese People's Liberation Army, Beijing 100048, P.R. China.

Xi Shan Clinic, 309th Hospital of PLA, Beijing 100091, P.R. China.

出版信息

Oncol Lett. 2018 Nov;16(5):6045-6050. doi: 10.3892/ol.2018.9399. Epub 2018 Sep 5.

DOI:10.3892/ol.2018.9399
PMID:30333876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6176458/
Abstract

MicroRNAs (miRNAs) may serve important roles in the regulation of human non-small cell lung cancer (NSCLC) cell growth and apoptosis. To the best of our knowledge, the present study was the first to explore the role of miRNA-133a/epidermal growth factor receptor (EGFR) in regulating NSCLC cell growth and apoptosis via the AKT/extracellular signal-regulated kinase (ERK) signaling pathway. It was determined that miRNA-133a expression was lower in NSCLC tissue than in the adjacent mucosae. Additionally, EGFR expression in the NSCLC tissue was higher compared with in the adjacent mucosae. Furthermore, the upregulation of miRNA-133a in NSCLC cells suppressed cell growth and induced apoptosis. Upregulating miRNA-133a also increased caspase-3 protein expression, while suppressing that of EGFR, phosphorylated (p)-AKT and p-ERK in NSCLC cells. Therefore, the results of the current study demonstrated that miRNA-133a downregulates EGFR expression in NSCLC via the AKT/ERK signaling pathway. These findings provide insights into the function of miRNA-133a in NSCLC, as well as into the molecular mechanisms underlying the miRNA-133a-mediated downregulation of the EGFR/AKT/ERK signaling pathway in NSCLC.

摘要

微小RNA（miRNA）可能在人类非小细胞肺癌（NSCLC）细胞生长和凋亡的调控中发挥重要作用。据我们所知，本研究首次探讨了miRNA - 133a/表皮生长因子受体（EGFR）通过AKT/细胞外信号调节激酶（ERK）信号通路在调控NSCLC细胞生长和凋亡中的作用。研究发现，NSCLC组织中miRNA - 133a的表达低于相邻黏膜组织。此外，NSCLC组织中EGFR的表达高于相邻黏膜组织。而且，NSCLC细胞中miRNA - 133a的上调抑制了细胞生长并诱导了凋亡。上调miRNA - 133a还增加了caspase - 3蛋白的表达，同时抑制了NSCLC细胞中EGFR、磷酸化（p）-AKT和p - ERK的表达。因此，本研究结果表明，miRNA - 133a通过AKT/ERK信号通路下调NSCLC中EGFR的表达。这些发现为miRNA - 133a在NSCLC中的功能以及miRNA - 133a介导的NSCLC中EGFR/AKT/ERK信号通路下调的分子机制提供了见解。