Bell C D, Stadler J, Michowitz M, Inbar M
J Surg Oncol. 1987 May;35(1):63-9. doi: 10.1002/jso.2930350116.
Two biopsies of intraductal and invasive lobular carcinoma of the breast and 11 biopsies of intraductal and invasive carcinoma of the breast were examined by automated micromensurative techniques for mean nuclear area of carcinoma cells in intraductal and in invasive compartments. The nuclei of invasive carcinoma cells tended to be smaller when they invaded stroma as single cells or as "thin strands" than when they invaded as part of large sheets of cells. Cells in direct apposition with the stroma usually had smaller nuclei than cells which were found centrally in large confluent sheets of cells. Intraduct carcinoma cells approached, in size, invasive cells which formed confluent sheets, rather than cancer cells which invaded as single cells. The nuclei of cells which invaded in small groups were usually darker than those of cells in confluent sheets, which were usually more vesicular.
对2例乳腺导管内癌和浸润性小叶癌活检标本以及11例乳腺导管内癌和浸润性癌活检标本，采用自动微量测量技术检测导管内和浸润性成分中癌细胞的平均核面积。当浸润性癌细胞以单个细胞或“细条索”形式浸润间质时，其细胞核往往比以大片细胞形式浸润时更小。与间质直接相邻的细胞，其细胞核通常比在大片融合细胞中央发现的细胞的细胞核更小。导管内癌细胞在大小上接近形成融合片层的浸润性细胞，而非以单个细胞形式浸润的癌细胞。小群浸润的细胞的细胞核通常比融合片层中细胞的细胞核颜色更深，后者通常泡状结构更多。
