Sharashidze L K, Raĭkhlin N T, Topuriia I V
Vopr Onkol. 1985;31(6):25-33.
Differences in ultrastructurally-differentiated and undifferentiated cells distribution were established in such non-invasive and invasive histological patterns of breast cancer as medullar carcinoma, mucinous, adenoid-cystic and lobular invasive cancer by means of electron microscopy. It was shown that a certain histological pattern is not necessarily matched by a relevant degree of ultrastructural differentiation of tumor cells. Tumor tissues of a similar histological pattern sometimes revealed different ratios of ultrastructurally-differentiated and undifferentiated cells, which may be responsible for the peculiarities in the clinical behavior of the said neoplasms. These data should be taken into account in establishing ultrastructural diagnosis as well as prognostic evaluation of the findings of electron microscopic examination in cases of non-invasive and certain invasive forms of breast tumors.
通过电子显微镜,在乳腺癌的髓样癌、黏液癌、腺样囊性癌和小叶浸润癌等非侵袭性和侵袭性组织学模式中,确定了超微结构分化细胞和未分化细胞分布的差异。结果表明,特定的组织学模式不一定与肿瘤细胞的相应超微结构分化程度相匹配。相似组织学模式的肿瘤组织有时显示出超微结构分化细胞和未分化细胞的不同比例,这可能是上述肿瘤临床行为特点的原因。在对非侵袭性和某些侵袭性乳腺肿瘤病例进行超微结构诊断以及对电子显微镜检查结果进行预后评估时,应考虑这些数据。